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KMID : 1094720230280030379
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Biotechnology and Bioprocess Engineering
2023 Volume.28 No. 3 p.379 ~ p.385
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Impact of the Synthetic Scaffold Strategy on the Metabolic Pathway Engineering
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Kim-Ngan T. Tran
Ashokkumar Kumaravel
Hong Soon-Ho
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Abstract
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For the development of the efficient bio-refinery process or biochemical producer, metabolic engineering has become an attractive choice recently. However, engineered metabolic pathways often suffer from flux imbalances due to a lack of corresponding regulatory mechanisms associated with natural metabolism. The interaction among different enzymes within a metabolic pathway plays an important role in regulating the efficiency of metabolic processes. Consequently, the creation of protein scaffolds has helped with the spatial co-localization of proteins in metabolic engineering. Research on protein scaffolds indicated scaffold systems may enhance metabolic productivity further. In this review, the specificity, selectivity, and regulatory mechanisms of protein-protein interactions are discussed in the context of the important effects that they exert on various biological processes.
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KEYWORD
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scaffold protein, metabolic engineering, synthetic biology, Escherichia coli
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